Keywords
alpha-lipoic acid, cardiovascular diseases, blood lipid spectrum
How to Cite
Smaliukh, O., Svitlyk, H., Zaremba, O., & Zaremba-Fedchyshyn, O. (2022). Possibilities of alpha-lipoic acid application in cardiovascular diseases (literature review and own data). The Practitioner, (2-3), 35-39. Retrieved from https://plr.com.ua/index.php/journal/article/view/713
Abstract
Today, alpha-lipoic acid is known as a hepatoprotective drug, as an antioxidant, and is successfully used to treat various liver diseases, complications of diabetes, and many other conditions. Data on the cardioprotective properties of alpha-lipoic acid and research on its use in cardiovascular diseases are increasingly found in the literature. In this review, we will analyze the possibilities of using alpha-lipoic acid.
References
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4. Altunina NV, Lizogub VG, Bondarchuk OM. Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myocardial Infarction. Journal of Medicine and Life. 2020;13(1),32-36. doi: 10.25122/jml-2020-0018.
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6. Akbari M, Ostadmohammadi V, Tabrizi R, Mobini M, Lankarani KB, Moosazadeh M et al. The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutrition & Metabolism. 2018;15:39. doi.org/10.1186/s12986-018-0274-y
7. Aslfalah H, Jamilian M, Ansarihadipour H, Abdollahi M, Khosrowbeygi A. Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study. International Journal of Reproductive BioMedicine. 2020;18:1029-1038. doi.org/10.18502/ijrm.v18i12.80 24
8. Boccardi V, Taghizadeh M, Salek M, Sadegh J. Blood pressure lowering effects of alpha-lipoic acid supplementation: a meta-analysis of randomized controlled trials. Arterial Hypertension 2021;25(1):29-38. doi: 10.5603/AH.a2021.0001.
9. Bock E, Schneeweiss J. Ein Beitrag zur Therapie der Neuropathia diabetica. Munch. Med. Wochenschr. 1959;43:1911-1912.
10. Christianty FM, Suharjono, Susilo I, Khotib J. Preventive Effects of Alpha-Lipoic Acid on LipopolysaccharideInduced Endothelial Dysfunction in Rats. Pharmaceutical Sciences and Research. 2019;6(2):124-130.
11. Deng C, Sun Z, Tong G, Yi W, Ma L, Zhao B et al. α-Lipoic Acid Reduces Infarct Size and Preserves Cardiac Function in Rat Myocardial Ischemia/ Reperfusion Injury through Activation of PI3K/Akt/Nrf2 Pathway. Plos One. 2013;8(3):е58371. doi.org/10.1371/journal.pone.0058371
12. Dudek M, Knutelska J, Bednarski M, Nowiński L, Zygmunt M, Bilska-Wilkosz A et al. Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts. Pharmacological reports. 2014;66(3):499-504. doi: 10.1016/j. pharep.2013.11.001.
13. EL Midaoui A, de Champlain J. Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid. Hypertension. 2002;39:303-307. doi.org/10.1161/hy0202.104345
14. Elfeky W, El-Afify DR. Effect of Alpha-Lipoic Acid on Atrial Fibrillation after Open Heart Surgery. The Egyptian Cardiothoracic Surgeon. 2020; 2(3):77-83.
15. Ghibu S, Carole R, Vergely C, Zeller M, Cottin Y, Rochette L. Antioxidant Properties of an Endogenous Thiol: Alpha-lipoic Acid, Useful in the Prevention of Cardiovascular Diseases. Journal of Cardiovascular Pharmacology. 2009;54(5):391-398. doi: 10.1097/FJC.0b013e3181be7554.
2. Данильченко ЛІ. Наукове обґрунтування пріоритетних напрямків розвитку медичної допомоги кардіологічним хворим в умовах міста. Світ медицини та біології. 2017;2(60):35-39.
3. Ahmad VN, Mohd A, Ruslan NB, Zain M, Maa R, Aizat M, Rahim A. Pathogenesis of atherosclerosis and alpha lipoic acid as a potencial therapeutic agent against atherosclerosis — a review. Journal of Translational Engineering in Health and Medicine. 2020;23(2):42-48.
4. Altunina NV, Lizogub VG, Bondarchuk OM. Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myocardial Infarction. Journal of Medicine and Life. 2020;13(1),32-36. doi: 10.25122/jml-2020-0018.
5. Amom Z, Zakaria Z, Mohamed J, Azlan A, Bahari H, Taufik Hidayat Baharuldin M et al. Lipid lowering effect of antioxidant alpha-lipoic Acid in experimental atherosclerosis. Journal of Clinical Biochemistry and Nutrition. 2008;43:88-94. doi: 10.3164/jcbn.2008051.
6. Akbari M, Ostadmohammadi V, Tabrizi R, Mobini M, Lankarani KB, Moosazadeh M et al. The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutrition & Metabolism. 2018;15:39. doi.org/10.1186/s12986-018-0274-y
7. Aslfalah H, Jamilian M, Ansarihadipour H, Abdollahi M, Khosrowbeygi A. Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study. International Journal of Reproductive BioMedicine. 2020;18:1029-1038. doi.org/10.18502/ijrm.v18i12.80 24
8. Boccardi V, Taghizadeh M, Salek M, Sadegh J. Blood pressure lowering effects of alpha-lipoic acid supplementation: a meta-analysis of randomized controlled trials. Arterial Hypertension 2021;25(1):29-38. doi: 10.5603/AH.a2021.0001.
9. Bock E, Schneeweiss J. Ein Beitrag zur Therapie der Neuropathia diabetica. Munch. Med. Wochenschr. 1959;43:1911-1912.
10. Christianty FM, Suharjono, Susilo I, Khotib J. Preventive Effects of Alpha-Lipoic Acid on LipopolysaccharideInduced Endothelial Dysfunction in Rats. Pharmaceutical Sciences and Research. 2019;6(2):124-130.
11. Deng C, Sun Z, Tong G, Yi W, Ma L, Zhao B et al. α-Lipoic Acid Reduces Infarct Size and Preserves Cardiac Function in Rat Myocardial Ischemia/ Reperfusion Injury through Activation of PI3K/Akt/Nrf2 Pathway. Plos One. 2013;8(3):е58371. doi.org/10.1371/journal.pone.0058371
12. Dudek M, Knutelska J, Bednarski M, Nowiński L, Zygmunt M, Bilska-Wilkosz A et al. Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts. Pharmacological reports. 2014;66(3):499-504. doi: 10.1016/j. pharep.2013.11.001.
13. EL Midaoui A, de Champlain J. Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid. Hypertension. 2002;39:303-307. doi.org/10.1161/hy0202.104345
14. Elfeky W, El-Afify DR. Effect of Alpha-Lipoic Acid on Atrial Fibrillation after Open Heart Surgery. The Egyptian Cardiothoracic Surgeon. 2020; 2(3):77-83.
15. Ghibu S, Carole R, Vergely C, Zeller M, Cottin Y, Rochette L. Antioxidant Properties of an Endogenous Thiol: Alpha-lipoic Acid, Useful in the Prevention of Cardiovascular Diseases. Journal of Cardiovascular Pharmacology. 2009;54(5):391-398. doi: 10.1097/FJC.0b013e3181be7554.
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