Keywords
radiation-induced acquired heart defects, Hodgkin’s lymphoma, asymptomatic aortic disease, consequences of radiation therapy for mediastinal tumours
How to Cite
Bek, N., & Radchenko, O. (2018). RADIATION-INDUCED CARDIAC VALVE DISEASE (LITERATURE REVIEW AND CLINICAL CASE). The Practitioner, (2), 16-20. Retrieved from https://plr.com.ua/index.php/journal/article/view/13
Abstract
Radiation-induced cardiac valve disease is a delayed consequence of the radiation therapy for mediastinal tumours. It can run a long, asymptomatic course and be diagnosed decades after the exposure. Aim: The study aims at evaluating the contemporary status of the problem of radiation-induced cardiac valve disease based on the review of the literature and clinical observation. Materials and methods: The literature was reviewed in the PubMed engine, typing the key words that included radiation-induced cardiac valve disease, side effects of radiation/beam therapy, cardiovascular risk. The paper describes the clinical case of a 50-year-old female patient who received radiation treatment for Hodgkin’s lymphoma at the age of 18. Results and discussion: The literature data was analysed with regard to the frequency, mechanisms, nosological relationship, features of the clinical picture, diagnosis and treatment for radiation-induced cardiac valve disease. A clinical case of low-symptomatic, first-diagnosed combined aortic defect with prevalent stenosis (degree 4) with normal-sized cardiac chambers was described. Conclusion: Radiation-induced acquired heart defects are asymptomatic and must be of medical concern.
References
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21. Radiation-induced valvular heart disease in Hodgkin’s disease is associated with characteristic thickening and fibrosis of aortic-mitral curtain / M.D. Brand, C.A. Abadi, G.P. Aurigemma [et al.] // J. Heart Valve Dis. — 2001. — Vol. 10. — P. 681-685.
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24. Schultz-Hector S. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? / S. Schultz-Hector, K.K. Trott // Int. J. Radiat. Oncol. Biol. Phys. — 2007. — Vol. 67, No 1. — P. 10-18.
25. Valvular abnormalities detected by echocardiography in 5-year survivors of children cancer: a long-term follow-up study / H.J. Van der Pal, I.W. van Dijk, R.B. Geskus [et al.] // Inf. J. Radiat. Oncol. Biol. Phys. — 2015. — Vol. 91. — P. 213-222.
26. Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of hodgkin lymphoma treated with radiation therapy / M.C. Hull, C.G. Morris, C.J. Pepine, N.P. Mendenhall // JAMA. — 2003. — Vol. 290, No 21. — P. 2831-2837.
27. Yusuf S.W. Radiation-induced heart disease: a clinical update / S.W. Yusuf, S. Sami, I.N. Dahner // Cardiol. Res. Pract. — 2011. — Access mode: https://doi. org/10.4061/2011/317659
2. Boerma M. Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease / M. Boerma, M. Hauer-Jensen // Cardiol. Res. Pract. — 2011. — Access mode: https://doi.org/10.4061/2011/858262
3. Cardiovascular complications of radiation therapy for thoracic malignancies: the role of non-invasive imaging for detection of cardiovascular disease / J.D. Groarke, P.L. Nguyen, A. Nohria [et al.] // Eur. Heart J. — 2014. — Vol. 35, No 10. — P. 612-623.
4. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkin’s lymphoma: an analysis from the St. Jude Lifetime Cohort Study / N. Bhakta, F. Liu, M. Baassiri [et al.] // Lancet Oncol. — 2016. — Vol. 17, No 9. — P. 1325-1334.
5. Detection of late radiation damage of left atrial fibrosis using cardiac late gadolinium enhancement magnetic resonance imaging / Y.J. Huany, A. Harrison, V. Sarkar [et al.] // Advances in Radiation Oncology. — 2016. — Vol. 1, No 2. — P. 106-114.
6. Ewer M.S. Cardiotoxity of anticancer treatments / M.S. Ewer, S.M. Ewer // Nature Reviews Cardiology. — 2011. — Vol. 12. — P. 547-558.
7. Expert consensus for multi-modality imeging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of cardiovascular Imaging and the American Society of Echocardiography / P. Lancellotti, V.T. Nkomo, L.P. Badano [et al.] // Eur. Heart J. — Cardiovasc. Imaging. — 2013. — Vol. 14, No 8. — P. 721-740.
8. High Risk of Symptomatic Cardiac Events in Childhood Cancer Survivors / H.J. van der Pal, E.C. van Dalen, E. van Delden [et al.] // J. Clin. Oncol. — 2012. — Vol. 30, No 13. — P. 1429-1437.
9. Increased aorto-mitral curtain thickness independently predicts mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery / M.Y. Desai, W. Wu, A. Masri [et al.] // Ann. Thorac. Surg. — 2014. — Vol. 97, No 4. — P. 1348-1355.
10. Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup // E.A. M. Feijen, A. Font-Conzalez, E.C. van Dalen [et al.] // Plos One. — 2016. — Vol. 11, No 9. — Access mode: http://10.1371/jornal.pone.0162778
11. Long-Term Outcomes of Patients With Mediastinal Radiotion-Assotiated Severe Aortic Stenosis and Subsequent Surgical Aortic Valve Replacement: A Matched Cohort Stady / E. Donnellan, A. Masry, G.B. Pettersson [et al.] // J. Am. Heart Assoc. — 2017. — Vol. 5, 6. — No 5. — Access mode: https://w.w.w.ncbi.nim.nih. gov/labs/ articles/28476874/
12. Mack M.J. Risk scores for predicting outcomes in valvular heart disease: How useful? / M.J. Mack // Curr. Cardiol. Rep. — 2011. — Vol. 13, No 2. — P. 107-112.
13. Maraldo M.V. Minimizing Cardiac Risks with Contemporary Radiatin Therapy for Hodgkin Lymphoma / M.V. Maraldo, A.K. Ng // J. Clin. Oncol. — 2016. — Vol. 34, No 3. — P. 208-210.
14. Minimizing late effects for patients with mediastinal Hodgkin lymphoma: deep inspiration breath -hold, IMRT, or both? / M.C. Aznar, M.V. Maraldo, D.A. Schut [et al.] // Int. J. Radiat. Oncol. Biol. Phys. — 2015. — Vol. 92, № 1. — P. 169-174.
15. Novel concepts in radiation-induced cardiovascular disease / J.R. Cuomo, G.K. Sharma, R.D. Conger, N.L. Weintraub // World J. Cardiol. — 2016. — Vol. 8, No 9. — P. 504-519.
16. Pulmonary fibrosis on multidetector computed tomography and mortaly in patients with radiation-associated cardiac disease undergoing cardiac surgery // M.Y. Desai, K. Karunakaravel, W. Wu, S. Agarwal [et al.] // Thorac. Cardiovasc. Surg. — 2016. — Vol. 148, No 2. — P. 475-481.
17. Radiation-associated valvular disease / R.G. Carlson, W.R. Mayfield, S. Norman, J.A. Alexander // Chest. — 1991. — Vol. 99. — P. 538-545.
18. Radiation-induced heart disease: A practical guide to diagnosis and management / E. Donnellan, D. Phelan, C.P. McCarthy [et al.] // Cleveland Clinic. Journal of Medicine. — 2016. — Vol. 83, No 12. — P. 914-922.
19. Radiation induces osteogenesus in human aortic valve interstitial cells / N.A. Nadlonek, M.J. Weyant, J.A. Yu [et al.] // J. Thorac. Cardiovasc. Surg. — 2012. — Vol. 144, No 6. — P. 1466-1470.
20. Radiation-induced valvular disease is the logical consequence of irradiation / A. Tamura, V. Takahara, K. Mogy, M. Katsumata // Gen. Thorac. Cardiovasc. Surg. — 2007. — Vol. 55, No 2. — P. 53-56.
21. Radiation-induced valvular heart disease in Hodgkin’s disease is associated with characteristic thickening and fibrosis of aortic-mitral curtain / M.D. Brand, C.A. Abadi, G.P. Aurigemma [et al.] // J. Heart Valve Dis. — 2001. — Vol. 10. — P. 681-685.
22. Radiation-related heart disease: current knowledge and future prospects / S.C. Darby, D.J. Cutter, M. Boerma [et al.] // Int. J. Radiat. Oncol. Biol. Phys. — 2010. — Vol. 76, No 3. — P. 656-665.
23. Risk of valvular heart disease after treatment for Hodgkin lymphoma / D.J. Cutter, M. Schaapveld, S.C. Darby [et al.] // J. Natl. Cancer Inst. — 2015. — Vol. 107, No 4. — Access mode: https://10.1093/jnci/ djv008
24. Schultz-Hector S. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? / S. Schultz-Hector, K.K. Trott // Int. J. Radiat. Oncol. Biol. Phys. — 2007. — Vol. 67, No 1. — P. 10-18.
25. Valvular abnormalities detected by echocardiography in 5-year survivors of children cancer: a long-term follow-up study / H.J. Van der Pal, I.W. van Dijk, R.B. Geskus [et al.] // Inf. J. Radiat. Oncol. Biol. Phys. — 2015. — Vol. 91. — P. 213-222.
26. Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of hodgkin lymphoma treated with radiation therapy / M.C. Hull, C.G. Morris, C.J. Pepine, N.P. Mendenhall // JAMA. — 2003. — Vol. 290, No 21. — P. 2831-2837.
27. Yusuf S.W. Radiation-induced heart disease: a clinical update / S.W. Yusuf, S. Sami, I.N. Dahner // Cardiol. Res. Pract. — 2011. — Access mode: https://doi. org/10.4061/2011/317659
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