Keywords
metabolic syndrome, predictors of complications, insulin resistance, postprandial hyperglycemia, glycosylation, inflammation.
How to Cite
Korolyuk, O., & Radchenko, O. (2013). Prognostic value of criteria of metabolic syndrome in patients with ischemic heart disease and newly diagnosed hyperglycemia. The Practitioner, (4), 46-51. Retrieved from https://plr.com.ua/index.php/journal/article/view/410
Abstract
116 patients observed for 40 months were investigated with the aim of establishing the prognostic value of metabolic syndrome and its components for occurrence of diabetes mellitus and acute cardiovascular complications in patients with ischemic heart disease and newly diagnosed hyperglycemia. With the help of Kaplan-Meier analysis it was shown that abdominal obesity, arterial pressure level and signs of diabetic dyslipidemia had less expressed influence on occurrence of complications in patients with ischemic heart disease and newly diagnosed hyperglycemia than glycemic components of metabolic syndrome. Common predictors of diabetes mellitus and acute cardiovascular complications included insulin resistance, postprandial hyperglycemia, glycosylation increase and activation of inflammation.
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Journal of Diabetology. - 2010. - Vol. 2. - P. 5-13.
3. Duvnjak L. The metabolic syndrome - an ongoing story / L. Duvnjak, M. Duvnjak // Journal of physiology and pharmacology. - 2009. - Vol. 60, Suppl 7. - P. 19-24.
4. Relationships among insulin resistance, obesity, diagnosis of the metabolic syndrome and cardio-metabolic risk / M. Salazar, H. Carbajal, W. Espeche [et al.]
// Diabetes & Vascular Disease Research. - 2011. - Vol. 8. - P. 109-116.
5. Homeostasis model assessment: insulin resistance and β cell function from fasting plasma glucose and insulin concentration in man / D.R. Matthews, J.P. Hosker,
A.S. Rudenski [et al.] // Diabetologia. - 1985. - Vol. 28. - P. 412-419.
6. The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion (letter; comment) / N.J. Wareham, D.I. Phillips,
C.D. Byrne [et al.] // Diabet. Med. - 1995. - Vol. 12. - P. 931.
7. Діагностика і лікування метаболічного синдрому, цукрового діабету, предіабету і серцево-судинних захворювань: метод. рекомендації Робо-
чої групи Української асоціації кардіологів і Української асоціації ендокринологів / Ред. О.І. Мітченко, В.В. Корпачев. - Київ, 2009. - 45 с.
8. Мітченко О.І. Дисліпідемії: діагностика, профілактика та лікування: метод. рекомендації Робочої групи з проблем атеросклерозу та хроніч-
них форм ІХС та Робочої групи з проблем метаболічного синдрому, діабету та серцево-судинних захворювань Українського наукового товари-
ства кардіологів / О.І. Мітченко, М.І. Лутай. - К.: Четверта хвиля, 2007. - 56 с.
9. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. Report of a WHO/IDF Consultation / World Health Organization and
International Diabetes Federation. -Geneva, 2005.-46 p.
10. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for
management / M.J. Chapman, H.N. Ginsberg, P. Amarenco [et al.] // Eur. Heart J. - 2011. - Vol. 32. - P. 1345-1361.
11. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies / N. Sarwar, J. Danesh,
G. Eiriksdottir [et al.] // Circulation. - 2007. - Vol. 115. - P. 450-458.
12. Rydén L. Glucose perturbations and cardiovascular risk: Challenges and opportunities / L. Rydén, L. Mellbin // Diabetes and Vascular Disease Research. -
2012. - Vol. 9. - P. 170-176.
13. A new look at screening and diagnosing diabetes mellitus / C. Saudek, W. Herman, D. Sacks [et al.] // J. Clin. Endocrinol. Metab. - 2008. - Vol. 93. - P. 2447-2453.
14. Relationship between glycated haemoglobin and microvascular complications: is there a natural cut-off point for the diagnosis of diabetes? / C. Sabanayagam,
G. Liew, E.S. Tai [et al.] // Diabetologia. - 2009. - Vol. 52. - P. 1279-1289.
15. Buell C. Utility of A1C for diabetes screening in the 1999 2004 NHANES population / C. Buell, D. Kermah, M. Davidson // Diabetes Care. - 2007. - Vol. 30. - P. 2233-2235.
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