Ratio of blood biochemical parameters in medical practice: clinical-diagnostic value

Abstract

The aim of this paper was to make a review of usage of some standard biochemical parameters ratios, which have clinical and diagnostic value in practice of general practitioner or therapist. Albumin-to-globulin coefficient is a simple informative criterion of protein metabolism; its decrease to <1.2 shows superiority of catabolism over anabolism and, first of all, requires exclusion of presence of inflammation, diseases of liver and kidneys. Calculated ratios of lipid metabolism parameters can increase lipidogram significance. Atherogenic ratio is the simple informative criterion; its increase is an indicator of the need for
lipid-lowering therapy regardless of pathological condition. Usage of different enzyme ratios in clinics is often performed in case of disorders of liver and heart. It can accelerate diagnostic search and help to determine prognosis more accurately, but such analysis should be done with regard of organ specificity and localization of enzymes in the cell. Although determination of ratios of middle molecules as a measure of endogenous intoxication is not included into standard examination of patients in clinical circumstances, reducing of ratios MMM280/254, MMM238/280 and MMSM238/260 is a sign of increase of endogenous intoxication, which requires identification and correction of probable reasons. Interrelations between peroxidation processes and antioxidant
protection, according to their special parameters, needs further study and recommendations for use in medical practice.