Keywords
osteoarthritis, type 2 diabetes, obesity, diacerein, cytokines.
How to Cite
Zhuravlyova, L., & Oliinyk, M. (2016). Efficacy of treatment of osteoarthritis in patients with osteoarthritis, type 2 diabetes mellitus and obesity. The Practitioner, (4), 25-30. Retrieved from https://plr.com.ua/index.php/journal/article/view/176
Abstract
Purpose of the study. To study the effect of diacerein on the dynamics of the cytokine profile and course of the disease in patients with combined course of osteoarthritis (OA) and type 2 diabetes mellitus (DM). Materials and methods. The study was performed on 35 patients (10 men and 25 women), mean age 57.51±1.13 years with combined course of OA, type 2 DM and obesity. Results and discussion. Use of diacerein led to decrease of pain, stiffness and improving joint function. The levels of pro-inflammatory cytokines and C-reactive protein in blood decreased after 3 months of therapy. Conclusions. The findings suggest a positive impact of the using of diacerein in patients with combined course of OA, type 2 DM and obesity.
References
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5. Tatari H. The structure, physiology, and biomechanics of articular cartilage: injury and repair // Acta Orthop. Traumatol. Turc. — 2007. — Vol. 41. Suppl. 2. — P. 1-5.
6. Tchernot A., Despers J.P. Pathophysiology of human visceral obesity: an update // Physiol. Rev. — 2013. — Vol. 93, № 1. — P. 359-404.
7. Sokolove J., Lepus C.M. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations // Ther. Adv. Musculoskelet. Dis. — 2013. — Vol. 5, № 2. — P. 77-94.
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11. Wang X. Metabolic triggered inflammation in osteoarthritis / X. Wang, D. Hunter, J. Xu [et al.] // Osteoarthritis and Cartilage. — 2015. — Vol. 23, № 1. — P. 22-30.
12. Pereira D. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review / D. Pereira, D. Peleteiro, J. Araujo [et al.] // Osteoarthritis Cartilage. — 2011. — Vol. 19 (11). — P. 1270-85.
13. Santangelo K.S. Vivo reduction or blockade of interleukin‑1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis / K.S. Santangelo, G.J. Nuovo, A.L. Bertonein // Osteoarthritis and Cartilage. — 2012. — Vol. 20, № 12. — P. 1610-1618.
14. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials / R. Christensen, E. Bartels, A. Astrup [et al.] // Osteoarthritis Cartilage. — 2008. — Vol. 16 (4). — P. 399-408.
15. Zheng W.J. Efficacy and safety of diacerein in osteoarthritis of the knee: a randomized, multicenter, double-dummy, diclofenac-controlled trial in China, APLAR / W.J. Zheng, F.L. Tang, J. Li [et al.] // J. Rheumatology. — 2006. — Vol. 9 (1). — P. 64-69.
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