Analysis of the effectiveness of the use of alpha lipoic acid in patients with high cardiovascular risκ


alpha-lipoic acid, endothelial dysfunction, oxidative stress, atherosclerosis, high cardiovascular risκ, diabetes mellitus.

How to Cite

Zhuravlyova, L., & Lopina, N. (2019). Analysis of the effectiveness of the use of alpha lipoic acid in patients with high cardiovascular risκ. The Practitioner, (1), 31-40. Retrieved from


The article is devoted to the modern possibilities of using alpha-lipoic acid in high cardiovascular risκ patients, including type 2 diabetes mellitus, which accelerates damage to the vascular wall and the development of atherosclerosis. Particular attention is paid to the role of oxidative stress, atherogenic dyslipidemia and endothelial dysfunction, the need for multifactorial pathogenetic therapy in the prevention and treatment of vascular complications is substantiated. The characteristics of the effects of alpha-lipoic acid on the metabolic processes in the body, its role in the antioxidant defense system, as well as its cytoprotective, angioprotector properties are systematically described. Based on evidence from evidence-based medicine, detailed schemes for the use of alphalipoic acid preparations are given, and the rationality of its use in combination therapy regimens is substantiated.



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