Keywords
benign hyperbilirubinemias, Gilbert syndrome, Crigler-Najjar syndrome, Dubin-Johnson Syndrome and Rotor syndrome
How to Cite
Radchenko, O., & Korolyuk, O. (2023). Hereditary hyperbilirubinemias: diagnostic approach and management. Lecture for postgraduate medical students. The Practitioner, (4), 88-92. Retrieved from https://plr.com.ua/index.php/journal/article/view/784
Abstract
Hyperbilirubinemia appears as jaundice or icterus, which can usually be detected when the serum bilirubin level exceeds 34 μmol/L. There are different types of predominantly unconjugated and predominantly conjugated bilirubinemias. Diagnostic approach to patients with icterus or hyperbilirubinemia was proposed. Clinical presentation, diagnostic criteria
and principles of treatment are described for Gilbert syndrome, Crigler-Najjar syndrome, Dubin-Johnson Syndrome and Rotor syndrome. Conclusion: benign hyperbilirubinemias are rare syndromes but can be distinguished from other liver injures with difficulties.
References
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2. Guerra Ruiz A.R., Crespo J., López Martínez R.M., et al. "Measurement and clinical usefulness of bilirubin in liver disease" Advances in Laboratory Medicine/Avances en Medicina de Laboratorio.2021; 2(3):352-361. https://doi.org/10.1515/almed-2021-0047
3. Pavlovic Markovic A, Stojkovic Lalosevic M, Mijac D, Milovanovic T, Dragasevic S, Sokic Milutinovic A, Krstic M N. Jaundice as a Diagnostic and Therapeutic Problem: A General Practitioner’s Approach. Dig Dis.2022;40:362-369. doi: 10.1159/000517301
4. https://www.amboss.com/us/knowledge/jaundice-and-cholestasis
5. Wagner KH, Shiels RG, Lang CA, et al. Diagnostic criteria and contributors to Gilbert’s syndrome. Critical Reviews in Clinical Laboratory Sciences, 2018;55:2, 129-139, DOI: 10.1080/10408363.2018.1428526
6. VanWagner LB, Green RM. Evaluating elevated bilirubin levels in asymptomatic adults. JAMA. 2015 3;313(5):516-7. doi: 10.1001/jama.2014.12835
7. Радченко О.М. Доброякісні гіпербілірубінемії (спадкові пігментні гепатози) та їх місце у практиці сімейного лікаря. Здоров’я України.2021;10:57-59. Темат. випуск «Гастроентерологія. Гепатологія. Колопроктологія».2021;2:28-30.
2. Guerra Ruiz A.R., Crespo J., López Martínez R.M., et al. "Measurement and clinical usefulness of bilirubin in liver disease" Advances in Laboratory Medicine/Avances en Medicina de Laboratorio.2021; 2(3):352-361. https://doi.org/10.1515/almed-2021-0047
3. Pavlovic Markovic A, Stojkovic Lalosevic M, Mijac D, Milovanovic T, Dragasevic S, Sokic Milutinovic A, Krstic M N. Jaundice as a Diagnostic and Therapeutic Problem: A General Practitioner’s Approach. Dig Dis.2022;40:362-369. doi: 10.1159/000517301
4. https://www.amboss.com/us/knowledge/jaundice-and-cholestasis
5. Wagner KH, Shiels RG, Lang CA, et al. Diagnostic criteria and contributors to Gilbert’s syndrome. Critical Reviews in Clinical Laboratory Sciences, 2018;55:2, 129-139, DOI: 10.1080/10408363.2018.1428526
6. VanWagner LB, Green RM. Evaluating elevated bilirubin levels in asymptomatic adults. JAMA. 2015 3;313(5):516-7. doi: 10.1001/jama.2014.12835
7. Радченко О.М. Доброякісні гіпербілірубінемії (спадкові пігментні гепатози) та їх місце у практиці сімейного лікаря. Здоров’я України.2021;10:57-59. Темат. випуск «Гастроентерологія. Гепатологія. Колопроктологія».2021;2:28-30.
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