Abstract
Anemia and iron deficiency are common comorbid conditions in patients with chronic heart failure (CHF), particularly
among elderly and senile individuals. They are associated with reduced quality of life, decreased physical capacity, and increased
rates of hospitalization and mortality. The aim of this study is to summarize current data on the pathogenesis, clinical significance,
diagnosis, and treatment of anemia in patients with CHF. It has been demonstrated that iron deficiency may adversely affect
the course of CHF even in the absence of anemia. The necessity of screening and an individualized therapeutic approach is
substantiated.
References
McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-3726. doi:10.1093/eurheartj/ehab368
Global Burden of Disease 2019 Cancer Collaboration, Kocarnik JM, Compton K, et al. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2022;8(3):420-444. doi:10.1001/jamaoncol.2021.6987
Cappellini MD, Comin-Colet J, de Francisco A, et al. Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management. Am J Hematol. 2017;92(10):1068-1078. doi:10.1002/ajh.24820
Oyedeji CI, Artz AS, Cohen HJ. How I treat anemia in older adults. Blood. 2024;143(3):205-213. doi:10.1182/blood.2022017626
Alnuwaysir RIS, Grote Beverborg N, Hoes MF, et al. Additional burden of iron deficiency in heart failure patients beyond the cardio-renal anaemia syndrome: findings from the BIOSTAT-CHF study. Eur J Heart Fail. 2022;24(1):192-204. doi:10.1002/ejhf.2393
McMurray JJ, Anand IS, Diaz R, et al. Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF). Eur J Heart Fail. 2013;15(3):334-341. doi:10.1093/eurjhf/hfs204
Macdougall IC, Canaud B, de Francisco AL, et al. Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency. Eur J Heart Fail. 2012;14(8):882-886. doi:10.1093/eurjhf/hfs056
Bianchi VE, von Haehling S. The treatment of chronic anemia in heart failure: a global approach. Clin Res Cardiol. 2024;113(8):1117-1136. doi:10.1007/ s00392-023-02275-4
Anand IS, Gupta P. Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies. Circulation. 2018;138(1):80-98. doi:10.1161/ CIRCULATIONAHA.118.030099
Streng KW, Nauta JF, Hillege HL, et al. Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction. Int J Cardiol. 2018;271:132-139. doi:10.1016/j.ijcard.2018.04.001