Keywords
heart valve calcification, aortic valve, risk factors, preventive treatment.
How to Cite
Kryvenko, V., Kachan, I., Fedorova, O., Kolesnyk, M., Nepryadkina, I., Pachomova, S., Borodavko, O., & Borota, D. (2021). Heart valve calcinosis: a modern view on the problem and research prospects. The Practitioner, (3), 15-21. Retrieved from https://plr.com.ua/index.php/journal/article/view/651
Abstract
Cardiac valve calcification (CVC), or calcifying aortic valve disease (a term primarily used in the United States and Europe), is the most common form of aortic valve stenosis worldwide. Modern research has changed the previous ideas about CVC as a degenerative, passive process and indicate, that valve calcification is, in fact, an active and multifaceted disease, involving the processes of lipoprotein deposition, chronic inflammation, osteoblastic transformation of valve interstitial cells and active leaflet calcification of valve. This review focuses on the pathogenetic and pathomorphological aspects of CVС, clinical and genetic risk
factors, as well as the potential of non-invasive, preventive treatment of CVС, outlines the scope of urgent problems requiring further study.
References
1. Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation / Dal-Bianco JP, Aikawa E, Bischoff JL [et al.]. Circulation. 2009;120:334-342.
2. Aortic valve calcification in chronic kidney disease / Rattazzi M, Bertacco E, Sekhri A [et al.]. Nephrol. Dial. Transplant. 2013 Dec;28(12):2968-76.
3. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of ‘degenerative’ valvular aortic stenosis / O’Brien KD, Reichenbach DD, Caulfield MT [et al.]. Arterioscler Thromb Vasc Biol. 1996;16:523-532.
4. Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis / Mohty D, Pibarot P, Despres JP [et al.]. Arterioscler Thromb. Vasc. Biol. 2008;28:187-193.
5. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma / O’Brien KD, Shavelle DM, Caulfield MT [et al.]. Circulation. 2002;106:2224-2230.
6. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly / Otto CM, Lind BK, Kitzman DW [et al.]. N. Engl. J. Med. 1999;341:142-147.
7. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway / Rajamannan NM, Subramaniam M, Caira F [et al.]. Circulation. 2005; 112: 1229-1234.
8. Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease / Nsaibia MJ, Mahmut A, Boulanger MC [et al.]. J. Intern. Med. 2016 Nov;280(5):509-517.
9. Bicuspid aortic valve: Identifying knowledge gaps and rising to the challenge from the international bicuspid aortic valve consortium (BAVCon) / Michelena HI, Prakash SK, Della Corte A [et al.]. Circulation. 2014; 129:2691-2704.
10. Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification / Gomes-Stallons MV, Wirrig-Schwendeman EE, Hassel KR [et al.]. Arterioscler. Thromb. Vasc. Boil. 2016 Jul;36(7):1398-405.
11. Calcific aortic stenosis / Lindman BR, Clavel M-A, Mathieu P [et al.]. Nat Rev Dis Primers. 2016;2:16006.
12. Calcific aortic stenosis and its correlation with a novel inflammatory marker, the lymphocyte/monocyte ratio / Efe TH, Gayretli Yayla K, Yayla C [et al.]. Rev. Port. Cardiol. 2016 Sep 30; S0870-2551(16):30194-9.
13. Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group / Rajamannan NM, Evans FJ, Aikawa E [et al.]. Circulation. 2011; 124:1783-1791.
14. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation / Rajamannan NM, Nealis TB, Subramaniam M [et al.]. Circulation. 2005; 111:3296-3301.
15. Coffey S. The prevalence, incidence, progression, and risks of aortic valve sclerosis: a systematic review and meta-analysis / Coffey S, Cox B, Williams MJ. J. Am. Coll. Cardiol. 2014; 63:2852-2861.
2. Aortic valve calcification in chronic kidney disease / Rattazzi M, Bertacco E, Sekhri A [et al.]. Nephrol. Dial. Transplant. 2013 Dec;28(12):2968-76.
3. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of ‘degenerative’ valvular aortic stenosis / O’Brien KD, Reichenbach DD, Caulfield MT [et al.]. Arterioscler Thromb Vasc Biol. 1996;16:523-532.
4. Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis / Mohty D, Pibarot P, Despres JP [et al.]. Arterioscler Thromb. Vasc. Biol. 2008;28:187-193.
5. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma / O’Brien KD, Shavelle DM, Caulfield MT [et al.]. Circulation. 2002;106:2224-2230.
6. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly / Otto CM, Lind BK, Kitzman DW [et al.]. N. Engl. J. Med. 1999;341:142-147.
7. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway / Rajamannan NM, Subramaniam M, Caira F [et al.]. Circulation. 2005; 112: 1229-1234.
8. Autotaxin interacts with lipoprotein(a) and oxidized phospholipids in predicting the risk of calcific aortic valve stenosis in patients with coronary artery disease / Nsaibia MJ, Mahmut A, Boulanger MC [et al.]. J. Intern. Med. 2016 Nov;280(5):509-517.
9. Bicuspid aortic valve: Identifying knowledge gaps and rising to the challenge from the international bicuspid aortic valve consortium (BAVCon) / Michelena HI, Prakash SK, Della Corte A [et al.]. Circulation. 2014; 129:2691-2704.
10. Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification / Gomes-Stallons MV, Wirrig-Schwendeman EE, Hassel KR [et al.]. Arterioscler. Thromb. Vasc. Boil. 2016 Jul;36(7):1398-405.
11. Calcific aortic stenosis / Lindman BR, Clavel M-A, Mathieu P [et al.]. Nat Rev Dis Primers. 2016;2:16006.
12. Calcific aortic stenosis and its correlation with a novel inflammatory marker, the lymphocyte/monocyte ratio / Efe TH, Gayretli Yayla K, Yayla C [et al.]. Rev. Port. Cardiol. 2016 Sep 30; S0870-2551(16):30194-9.
13. Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group / Rajamannan NM, Evans FJ, Aikawa E [et al.]. Circulation. 2011; 124:1783-1791.
14. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation / Rajamannan NM, Nealis TB, Subramaniam M [et al.]. Circulation. 2005; 111:3296-3301.
15. Coffey S. The prevalence, incidence, progression, and risks of aortic valve sclerosis: a systematic review and meta-analysis / Coffey S, Cox B, Williams MJ. J. Am. Coll. Cardiol. 2014; 63:2852-2861.
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