Keywords
adipocytokines, the dysfunction of the pancreas, chronic pancreatitis, type 2 diabetes mellitus, metabolic syndrome.
How to Cite
Zhuravliova, L., & Shekhovtsova, Y. (2015). Influence of adipocytokines on the dysfunction of pancreas in type 2 diabetes mellitus. The Practitioner, (1), 76-82. Retrieved from https://plr.com.ua/index.php/journal/article/view/200
Abstract
The data of the impact adipocytokines on the dysfunction of the pancreas in chronic pancreatitis were analyzed in the article. The data of the resulting of contemporary literature allows to identify the role of some adipocytokines (apelin, TNF-α) in the development of diseases associated with obesity such as insulin resistance, type 2 diabetes mellitus and metabolic syndrome and to speculation about their involvement in pathophysiological processes in the pancreas, especially in the mechanisms of the development of chronic pancreatitis.
References
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10. Chen H. Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of akita mice / H. Chen, C. Zheng, X. Zhang et al. // Peptides. – 2011. – 32(8). – P. 1634-1639.
11. Chen X. TNF-alpha, a potent lipid metabolism regulator / X. Chen, K. Xun, L. Chen, Y. Wang // Cell Biochem. Funct. – 2009. – Vol.27(7). – Р. 407-416.
12. Colwell J.A. Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome / J.A. Colwell // JAMA. – 2011. – 306(2). – P. 215.
13. De Alvaro C. Tumor necrosis factor alpha produced insulin resistance in sceletal muscle by activation of inhibitor kappaBkinase in ap38 MARKdeppendent
manner / C. De Alvaro, T. Teruel, R. Hernandez, M. Lorenzo // J. Biol. Chem. – 2004. – Vol.279. – Р. 17070-17078.
14. Demydenko G. Apelin expression in patients with essential hypertension and prediabetes / Demydenko G., Kovalyova O. // 23rd European meeting on hypertension and cardiovascular protection. – Milan (Italy), June 14-17, 2013. – P. 323.
15. Dray C. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice / C. Dray, C. Knauf, D. Daviaud et al. // Cell. Metab. – 2008. – Vol. 8. – P. 437-445.
2. Солнцева А.В. Эндокринные эффекты жировой ткани / А.В. Солнцева // Медицинские новости. – 2009. – №3. – С. 7-11.
3. Andersson K. A nitric oxide-mediated mechanism regulates lipolysis in human adipose tissue in vivo / K. Andersson, N. Gaudiot, C. Ribiere et al. // Br. J. Pharmacol. – 1999. – Vol. 126. – P. 1639-1645.
4. Attane C. Apelin stimulated glucose uptake but not lipolysis in human adipose tissue ex vivo / C. Attane et all // Journal of Molecular Endocrinology. – 2011. – №46. – Р.21-28.
5. Beltowski J. Apelin and visfatin: unique «beneficial» adipokines upregulated in obersity? / J. Beltowski // Med. Sci. Monit. – 2006. – Vol.12. – P. 112-119.
6. Boucher J.А. Newly Identified Adipokine Up-Regulated by Insulin and Obesity / J. Boucher, B. Masri, D. le Daviaud et. al. // Endocrinology. – 2005. – 146(4). – Р. 1764-1771.
7. Bruun J.M. Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue / J.M. Bruun, A.S. Lihn, A.K. Madan et al. // Amer. J. Physiol. Endocrin. Metab. – 2004. – Vol. 286. – P. E8-E13.
8. Сeriello A. Postprandial hyperglycemia and diabetes complications: is it time to treat? / A. Сeriello // Diabetes. – 2005. – 54. – P.1-7.
9. Chen F.L. Adipophilin affects the expression of TNF-alpha, MCP-1, and IL-6 in THP-1 macrophages / F.L. Chen, Z.H. Yang, X.C. Wang et al. // Mol. Cell. Biochem. – 2010. – Vol.337. – Р. 193-199.
10. Chen H. Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of akita mice / H. Chen, C. Zheng, X. Zhang et al. // Peptides. – 2011. – 32(8). – P. 1634-1639.
11. Chen X. TNF-alpha, a potent lipid metabolism regulator / X. Chen, K. Xun, L. Chen, Y. Wang // Cell Biochem. Funct. – 2009. – Vol.27(7). – Р. 407-416.
12. Colwell J.A. Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome / J.A. Colwell // JAMA. – 2011. – 306(2). – P. 215.
13. De Alvaro C. Tumor necrosis factor alpha produced insulin resistance in sceletal muscle by activation of inhibitor kappaBkinase in ap38 MARKdeppendent
manner / C. De Alvaro, T. Teruel, R. Hernandez, M. Lorenzo // J. Biol. Chem. – 2004. – Vol.279. – Р. 17070-17078.
14. Demydenko G. Apelin expression in patients with essential hypertension and prediabetes / Demydenko G., Kovalyova O. // 23rd European meeting on hypertension and cardiovascular protection. – Milan (Italy), June 14-17, 2013. – P. 323.
15. Dray C. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice / C. Dray, C. Knauf, D. Daviaud et al. // Cell. Metab. – 2008. – Vol. 8. – P. 437-445.
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