Counteraction to intoxication with heavy metals: unique nephroprotective effects of plant peptides


heavy metals, mercury, nephropathy, plant peptides, GA‑40, nephroprotector, nephron, NF-kB, p53, apoptosis, detoxification.

How to Cite

Rogovyy, Y., Pechinka, A., Gogitidze, Z., & Konovalenko, S. (2019). Counteraction to intoxication with heavy metals: unique nephroprotective effects of plant peptides. The Practitioner, (3), 53-60. Retrieved from


The article discusses the main types of effects of heavy metals on the structure and functional state of the kidneys and focuses on the molecular mechanisms of the nephrotoxic effect of mercury. An experimental study of the nephroprotective properties of the immunotropic drug GA‑40 was conducted. During the study, it was established that GA‑40 reduces the content of mercury and tumor necrosis factor in the renal cortex at the polyuric stage of sublimated nephropathy, which positively affects the proximal nephron. Also, the experiment showed the anti-nephrosclerotic effect of GA‑40 during the chronic period of Masugi nephritis — this helps prevent atrophy of the tubules and glomeruli of the nephron by suppressing apoptosis. GA‑40 suppresses inflammation and prevents the occurrence of fibrotic changes on the background of damaged tissue. The high safety profile of GA‑40 provides the necessary conditions for the gradual restoration of the structure and function of the kidneys after poisoning with heavy metals, in particular mercury chloride, therefore the drug is considered as promising for the treatment of toxic nephropathy.



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