Keywords
non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, non-invasive biomarkers of liver steatosis and fibrosis.
How to Cite
Dynnyk, N. (2015). Nonalcoholic fatty liver disease: possibilities for noninvasive diagnostics. The Practitioner, (3), 36-40. Retrieved from https://plr.com.ua/index.php/journal/article/view/233
Abstract
The paper summarizes the data about the features of diagnosis of non-alcoholic fatty liver disease (NAFLD). The diagnosis of NAFLD can be made through imaging studies or liver biopsy with histologic confirmation. Although there are several non-invasive methods and biomarkers of stage of liver steatosis and fibrosis. The article represents results of study of sensitivity and specificity of different non-invasive methods of hepatic steatosis and fibrosis in different cohorts of patients.
References
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2. An obesity associated gut microbiome with increased capacity for energy harvest [Text] / P.J. Turnbaugh, R.E. Ley, M.A. Mahowald [et al.] // Nature. — 2006. — Vol. 444. — P. 1027-1031.
3. Antioxidant supplements for nonalcoholic fatty liver disease and/or steatohepatitis [Text] / F. Lirussi, L. Azzalini, S. Orando [et al.] // Cochrane Database Syst. Rev. — 2007. — Vol. 24. — CD004996.
4. Bahcecioglu I.H. Demographic and clinicopathological characteristics of nonalcoholic fatty liver disease in the east-southeastern Anatolia regions in Turkey [Text] / I.H. Bahcecioglu, M. Koruk, O. Yilmaz // Med. Princ. Pract. — 2006. — Vol. 15. — P. 62-68.
5. Barchetta I. Liver vitamin D3 receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus [Text] / I. Barchetta, S. Carotti, G. Labbadia // Hepatology. — 2012. — Vol. 56. — P. 2180-2187.
6. Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications [Text] / K. Cusi // Gastroenterology. — 2012. — Vol. 142. — P. 711-725.
7. Day C.P. Natural history of NAFLD: remarkably benign in the absence of cirrhosis [Text] / C.P. Day // Gastroenterology. — 2005. — Vol. 129. — P. 375-378.
8. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial [Text] / J.E. Lavine, J.B. Schwimmer, M.L. Van Natta [et al.] // JAMA. — 2011. — Vol. 305. — P. 1659-1668.
9. Furuya C.K. Jr. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years [Text] / C.K. Furuya Jr., C.P. Оliveira, E.S. de Mello // J. Gastroenterol. Hepatol. — 2007. — Vol. 22. — P. 510-514.
10. Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease [Text] / A. Suzuki, P. Angulo, J. Lymp [et al.] // Liver Int. — 2005. — Vol. 25. — P. 779-786.
11. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity [Text] / J. Henao-Mejia, E. Elinav, C. Jin [et al.] // Nature. — 2012. — Vol. 482. — P. 179-185.
12. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents [Text] / J.B. Schwimmer, N. Mc Greal, R. Deutsch [et al.] // Pediatrics. — 2005. — Vol. 115. — P. 561-565.
13. Managing nonalcoholic fatty liver disease. Recommendations for family physicians [Text] / I. Grattagliano, P. Portincasa, V.O. Palmieri, G. Palasciano // Can. Fam. Physician. — 2007. — Vol. 53. — P. 857-863.
14. Mc Cullough A.J. Pathophysiology of nonalcoholic steatohepatitis [Text] / A.J. Mc Cullough // J. Clin. Gastroenterol. — 2006. — Vol. 40. — P. 17-29.
15. Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity [Text] / R. Gambino, M. Cassader, G. Pagano [et al.] // Annals of Medicine. — 2011. — Vol. 43. — P. 617-649.
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