Abstract
This article explains clinical effects of resveratrol and biologically active substances contained in vine and grape seeds available in the Ukrainian market as Resverasin® natural complex in patients with cardiovascular diseases according to international literature data. The available evidence base has demonstrated positive dynamics of these components used in international practice for prevention of cardiovascular diseases in patients with lipid and carbohydrate exchange impairments and in overweight, obese, metabolic syndrome and cardiovascular disease patients as additional therapy to increase efficacy of the standard therapy.
References
1. Constant J. Alcohol, ischemic heart disease, and the French paradox // Coron. Artery Dis. — 1997.
2. Mezzano D. et al. Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors // Eur. J. Clin. Nutr. — 2001.
3. Catalgol B., Batirel S., Taga Y. and Kartal Ozer N. Resveratrol: French paradox revisited. Department of Biochemistry, Faculty of Medicine, Genetic and Metaboli Diseases Research Centr, Marmara University. — Istanbul, Turkey, 2012.
4. Clouatre D.L., Kandaswami C. Grape Seed Extract. Encyclopedian of Dietary Supplements. — 2005.
5. Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms // Genes Dev. — 1999. — Vol. 13. — P. 2570-2580.
6. Tissenbaum H.A., Guarente L. Increased dosage of a sir‑2 gene extends lifespan in Caenorhabditis elegans // Nature. — 2001. — Vol. 410. — P. 227-230.
7. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C. et al. Resveratrol improves health and survival of mice on a high-calorie diet // Nature. — 2006. — Vol. 444. — P. 337-342.
8. Brasnyo P., Molnbr G.A., Molnbs M., Marky L. et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients // Br. J. Nutr. — 2011. — Vol. 106. — P. 383-389.
9. Bhatt J.K., Thomas S., Nanjan M.J. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus // Nutr. Res. — 2012. — Vol. 32. — P. 537-541.
10. Kumar B.J., Joghee N.M. Resveratrol supplementation in patients with type 2 diabetes mellitus: a prospective, open label, randomized controlled trial // Int. Res. J. Pharm. — 2013. — Vol. 4 (8). — P. 246-249.
11. Movahed A., Nabipour I., Lieben L.X., Thandapilly S.J., Yu L., Kalantarhormozi M., Rekabpour S.J., Netticadan T. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients // Evid. Based Complement. Alternat. Med. — 2013.
12. Ashraf M.J., Baweja P. Obesity: the ‘huge’ problem in cardiovascular diseases // Mol. Med. — 2013. — Vol. 110. — P. 499-504.
13. Do G.M., Kwon E.Y., Kim H.J., Jeon S.M., Ha T.Y., Park T., Choi M.S. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice // Biochem. Biophys. Res. Commun. — 2008. — Vol. 374. — P. 55-59.
14. Gocmen A.Y., Burgucu D., Gumuslu S. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target // Appl. Physiol. Nutr. Metab. — 2011. — Vol. 36. — P. 323-330.
15. Chen M.L., Yi L., Jin X., Liang X.Y., Zhou Y., Zhang T., Xie Q., Zhou X., Chang H., Fu Y.J., Zhu J.D., Zhang Q.Y., Mi M.T. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway // Autophagy. — 2013. — Vol. 9. — P. 2033-2045.
2. Mezzano D. et al. Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors // Eur. J. Clin. Nutr. — 2001.
3. Catalgol B., Batirel S., Taga Y. and Kartal Ozer N. Resveratrol: French paradox revisited. Department of Biochemistry, Faculty of Medicine, Genetic and Metaboli Diseases Research Centr, Marmara University. — Istanbul, Turkey, 2012.
4. Clouatre D.L., Kandaswami C. Grape Seed Extract. Encyclopedian of Dietary Supplements. — 2005.
5. Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms // Genes Dev. — 1999. — Vol. 13. — P. 2570-2580.
6. Tissenbaum H.A., Guarente L. Increased dosage of a sir‑2 gene extends lifespan in Caenorhabditis elegans // Nature. — 2001. — Vol. 410. — P. 227-230.
7. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C. et al. Resveratrol improves health and survival of mice on a high-calorie diet // Nature. — 2006. — Vol. 444. — P. 337-342.
8. Brasnyo P., Molnbr G.A., Molnbs M., Marky L. et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients // Br. J. Nutr. — 2011. — Vol. 106. — P. 383-389.
9. Bhatt J.K., Thomas S., Nanjan M.J. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus // Nutr. Res. — 2012. — Vol. 32. — P. 537-541.
10. Kumar B.J., Joghee N.M. Resveratrol supplementation in patients with type 2 diabetes mellitus: a prospective, open label, randomized controlled trial // Int. Res. J. Pharm. — 2013. — Vol. 4 (8). — P. 246-249.
11. Movahed A., Nabipour I., Lieben L.X., Thandapilly S.J., Yu L., Kalantarhormozi M., Rekabpour S.J., Netticadan T. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients // Evid. Based Complement. Alternat. Med. — 2013.
12. Ashraf M.J., Baweja P. Obesity: the ‘huge’ problem in cardiovascular diseases // Mol. Med. — 2013. — Vol. 110. — P. 499-504.
13. Do G.M., Kwon E.Y., Kim H.J., Jeon S.M., Ha T.Y., Park T., Choi M.S. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice // Biochem. Biophys. Res. Commun. — 2008. — Vol. 374. — P. 55-59.
14. Gocmen A.Y., Burgucu D., Gumuslu S. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target // Appl. Physiol. Nutr. Metab. — 2011. — Vol. 36. — P. 323-330.
15. Chen M.L., Yi L., Jin X., Liang X.Y., Zhou Y., Zhang T., Xie Q., Zhou X., Chang H., Fu Y.J., Zhu J.D., Zhang Q.Y., Mi M.T. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway // Autophagy. — 2013. — Vol. 9. — P. 2033-2045.
Downloads
Download data is not yet available.