Comparative analysis of estimating equations of renal function in patients with osteoarthritis

Abstract

Purpose of the study was to compare the estimating equations of renal function (MDRD, CKD-EPI and Cockroft-Gault) in patients with osteoarthritis (OA). Methods. We compared the performance of MDRD, CKD-EPI, Cockroft-Gault equations in 492 patients with OA, average age — 62.6±9.7. Subgroups for analysis were defined by glomerular filtration rate, sex, age, body mass index (BMI), diabetes status and serum creatinine. Results. When we used Cockroft-Gault equation, the number of patients with chronic kidney disease stage III was lower comparing with CKD-EPI and MDRD equations (p˂0.001). Glomerular filtration rate (GFR) / creatinine clearance (CrCl) means of analyzed methods didn’t differ when GFR was ˂60 mL/min. In patients with GFR≥60 mL/min differences
were not found between CKD-EPI and MDRD equations. We found no differences between GFR/CrCl in patients with BMI˂25 kg/m². Diagnostic value of Cockroft-Gault equation was lower comparing with MDRD and CKD-EPI equations. Conclusions. For estimation of GFR in patients with OA, CKD-EPI estimating equation is more accurate and more acceptable, than the Cockroft-Gault and MDRD.