Abstract
Chronic granulomatous disease is a primary immunodeficiency disorder, both X-linked and autosomal recessive, characterized by compromised function of the phagocytic immune system. The disease manifests through severe bacterial and fungal infections affecting the skin, lymph nodes, lungs, liver, and gastrointestinal tract. Pathomorphological features include excessive inflammation and the formation of granulomas. This article provides a comprehensive review of the literature on this disorder and presents a clinical case involving an 8-month-old child exhibiting a typical manifestation: severe mixed bacterialfungal pneumonia. It emphasizes the importance of early diagnosis and optimized treatment for chronic granulomatous disease in children.
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