Assessment of the functional status of the endothelium in patients with arterial hypertension and cardiovascular risk factors
No. 4 (2022), CARDIOVASCULAR DISEASES
No. 4 (2022)

Assessment of the functional status of the endothelium in patients with arterial hypertension and cardiovascular risk factors

CARDIOVASCULAR DISEASES
Published December 23, 2022
O. Makar
Львівський національний медичний університет ім. Данила Галицького
T. Solomenchuk
Львівський національний медичний університет ім. Данила Галицького
M. Kruchek
Медичний центр «Едем Медікал»
O. Bashkirtsev
Медичний центр «Едем Медікал»
O. Sorokopud
ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України»
G. Siabrenko
КНП «Обласний клінічний госпіталь ветеранів війни Кіровоградської обласної ради»
O. Klymkovych
Львівський національний медичний університет ім. Данила Галицького
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Keywords

endothelium-dependent vasodilatation, endothelium-independent vasodilatation, endothelial dysfunction, arterial hypertension

How to Cite

Makar, O., Solomenchuk, T., Kruchek, M., Bashkirtsev, O., Sorokopud, O., Siabrenko, G., & Klymkovych, O. (2022). Assessment of the functional status of the endothelium in patients with arterial hypertension and cardiovascular risk factors. The Practitioner, (4), 15-19. Retrieved from https://plr.com.ua/index.php/journal/article/view/730
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Abstract

Endothelial dysfunction is a recognized early marker of cardiovascular diseases. Although many factors affecting the state of the endothelium are known today, three are considered the main ones: arterial hypertension (AH), dyslipidemia, and smoking. The purpose of the study: to analyze the state of endothelial function by performing a cuff test in patients with and without AH, depending on other cardiovascular risk factors. Material and methods. 87 patients were examined (61 men and 26 women, average age 45±10 years). All patients were divided into two groups: Group I — patients with AH I-II stage (n=43) and Group II — patients without hypertension (n=44). To assess endothelial function, a cuff test was performed to determine endothelium-dependent (EDV) and endothelium-independent vasodilatation (EIV). Results. Proatherogenic changes in lipid spectrum were more pronounced in patients of group I. The average rate of EDV in patients of the I group for 15 s was 9.43±1.07% versus 13.16±1.2% in patients of the II group, and the average rate of EDV for 60 s was 12.09±1.16% and 16.8±1.23%, respectively, which indicates a violation of EDV in patients with AH. The average rate of EIV in patients of the 1st group at 1, 3 and 5 minutes
was 17.32±1.23%; 22.34±1.53% and 24.82±1.5%, respectively, which corresponded to normal indicators, but were significantly lower than the average value of this indicators in patients of II group: 21.47±1.27%; 28.13±1.52% and 30.08±1.53%, respectively. Correlation-regression analysis showed the significance of the influence of LDL, TG, HDL on the state of endothelial function in patients with AH, and the independent effect of smoking on the development of endothelial dysfunction regardless of the presence of hypertension. Conclusions. In patients with AH, signs of endothelial dysfunction were significantly more often detected, mostly due to violation of EDV, but indicators of EIV were worse than in patients without AH. Proatherogenic changes in the lipid spectrum of blood in patients with AH have a significant impact on EIV indicators, while an increased level of HDL can be considered a protective factor affecting both EDV and EIV. Smoking is associated with impaired endothelial function, regardless of the presence of AH.

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