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Abstract
Doctors use systolic (SBP), dyastolic (DBP) and pulse (PBP) blood pressure (BP) every day. Increase of PBP >60 mm Hg suggests of increased arterial stiffness and predicts cardiovascular events. This study was aimed at revealing of correlations between SBP, DBP, and PBP with clinical, laboratory, structural and functional parameters. Matherials and methods. We analyzed data of 342 patients with arterial hypertension of І-ІІІ grades, which underwent clinical and biochemical blood analysis, electrocardiography, echocardiography, and abdominal ultrasound. We studied Spearman correlations of BP with 78 parameters of clinical, laboratory and instrumental studies (Statistica 6.0, Statsoft, USA). Data is represented as median (lowest quartile; highest quartile). Results were considered significant if p<0.05. Results and discussion. SBP of the participants was 155.0 (145.0;165.0), ДDBP — 90.0 (80.0;100.0), PBP — 60,0(55,0;70,0) mm Hg. The highest number of significant correlations was revealed for DBP. As DBP was strongly associated with structural parameters of heart and aorta, it may potently influence the left ventricle (LV) remodeling. Only DBP was directly connected to erythrocytes and hemoglobin. PBP was inversely related to alaninaminotransferase and γ-glutamyltranspeptidase level, and directly — to right liver lobe size. The thickness of interventricular septum and LV wall, and also myocardial mass index directly correlated with all BP measures, whereas sizes and volumes of LV — only with DBP. SBP directly correlated with left atrium (LA) size and inversely — with the ratio of early and late diastolic filling of LV speeds (Е/А). Conclusions. DBP was characterized by the biggest amount of correlations with studied parameters, and associated with female sex, higher body mass, sizes and volumes of LV, atherogenic blood profile, and presence
of Helicobacter pylori. Increase of SBP correlated with age, increased LA, diastolic dysfunction, myocardial hypertrophy, presence of Helicobacter pylori, disorders of carbohydrate metabolism. Increase of PBP is a result of increase of SBP and decrease of DBP; is associated with older age, myocardial hypertrophy, and liver enlargement.
References
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