Keywords
lower limb venous insufficiency, treatment, Venosmin, efficiency, safety.
How to Cite
Lytvynenko, O., & Buhaitsov, S. (2015). Experience of the phlebotropic pharmacotherapy in chronic venous insufficiency. The Practitioner, (3), 17-20. Retrieved from https://plr.com.ua/index.php/journal/article/view/230
Abstract
The article presents data on the clinical study of the drug Venosmin. We studied the dynamics of the effect of the study drug for clinical signs of chronic venous insufficiency of the lower limbs. The study investigated the microcirculation and oxygen exchange in the tissues of the lower extremities using laser Doppler flowmetry. The study results suggest that the drug Venosmin has a high therapeutic efficacy in chronic venous insufficiency of the lower extremities. The drug was well tolerated. There is evidence that therapeutic efficacy of Venosmin is equivalent to the original phlebotropic drug.
References
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8. Сoleridge-Smith P., Lok C., Ramelet A.-A. Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purifield flavonoid fraction // Eur. J. Vasc. Endovasc. Surg. — 2005. — V. 30. — P. 198-2008
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10. Gohel M.S., Barwell J.R., Taylor M., Chant T., Foy C., Earnshaw J.J., Heather B.P., Mitchell D.C., Whyman M.R., Poskitt K.R. Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial // BMJ. — 2007. — Vol. 335 (7610). — Р. 83.
11. Kirsner R.S., Mata S.M., Falanga V. Split-thickness skin grafting of leg ulcers. The University of Miami Department of Dermatologvs experience (1990-1993) // Dermatol. Surg. —1995. — 21. — Р. 701-703.
12. Lacroix P., Aboyans V., Preux P.M. et al. Epidemiology of venous insufficiency in an occupational population // Int. Angiol. — 2003 — V. 22. — № 2 — Р. 172-176.
13. Perrin M. Хирургическое лечение венозных язв // Флеболимфология. — 2006. — 27. — Р. 7-10.
14. Ramelet A.-A., Boisseau M.R., Allegra C., Nicolaides A. et al. Veno-active drugs in the management of chronic venous disease. An international consensus statement: current medical position, prospective views and final resolution // Clin. Hemorheol. Microcirc. — 2005. — 33 (4). — Р. 309-319.
15. Vuerstaek J.D.D., Vainas T., Wuite J., Nelemans P., Neumann M.H.A. and Veraart J.C.J.M. State-of-the-art treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings // J. Vasc. Surg. — 2006. — Vol. 44. — Р. 1029-1038.
2. Чернуха Л.М. Синдром хронической лимфовенозной недостаточности нижних конечностей. Современный взгляд на проблему // Клін. хірургія. — 2002. — № 4. — С. 15-23.
3. Богачев В.Ю., Голованова О.В., Кузнецов А.Н. Хронический венозный отек (С3 по СЕАР): новые международные рекомендации и консенсусы // Ангиология и сосудистая хирургия. — 2013. — № 19 (3). — С. 75-828.
4. Barwell J.R., Taylor M., Deacon J. Surgical correction of isolated superficial venous reflux educes long-term reccurence rate in chronic venous leg ulcers // Eur. J. Vasc. Endovask. Surg. — 2000. — Oct., 20 (4). — P. 363-368.
5. Bergan J. Venous disorders: treatment with sclerosant foam // J. Cardiovasc. Surg. (Torino). — 2006. — Vol. 47, № 1. — P. 9-18.
6. Belcaro G., Cesarone M.R., De Sanctis M.T. Laser Doppler and transcutaneous oximetry: modern investigations to assess drug efficacy in chronic venous insufficiency // Int. J. Microcirc. Clin. Exp. — 1995; 15 Suppl; 1. — Р. 45-49.
7. Colerige-Smith Ph. D. From Skin Disoders to Venous Leg Ulcers: Pathophysiology and Efficacy of Daflon 500 mg in ulcer Healing // Angiology. — 2003. — V. 54. — Р. 45-50.
8. Сoleridge-Smith P., Lok C., Ramelet A.-A. Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purifield flavonoid fraction // Eur. J. Vasc. Endovasc. Surg. — 2005. — V. 30. — P. 198-2008
9. Danziger N. Pathophysiology of pain in venous disease // Phlebolymphology. — 2008. — Vol. 15. — Р. 107-114.
10. Gohel M.S., Barwell J.R., Taylor M., Chant T., Foy C., Earnshaw J.J., Heather B.P., Mitchell D.C., Whyman M.R., Poskitt K.R. Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial // BMJ. — 2007. — Vol. 335 (7610). — Р. 83.
11. Kirsner R.S., Mata S.M., Falanga V. Split-thickness skin grafting of leg ulcers. The University of Miami Department of Dermatologvs experience (1990-1993) // Dermatol. Surg. —1995. — 21. — Р. 701-703.
12. Lacroix P., Aboyans V., Preux P.M. et al. Epidemiology of venous insufficiency in an occupational population // Int. Angiol. — 2003 — V. 22. — № 2 — Р. 172-176.
13. Perrin M. Хирургическое лечение венозных язв // Флеболимфология. — 2006. — 27. — Р. 7-10.
14. Ramelet A.-A., Boisseau M.R., Allegra C., Nicolaides A. et al. Veno-active drugs in the management of chronic venous disease. An international consensus statement: current medical position, prospective views and final resolution // Clin. Hemorheol. Microcirc. — 2005. — 33 (4). — Р. 309-319.
15. Vuerstaek J.D.D., Vainas T., Wuite J., Nelemans P., Neumann M.H.A. and Veraart J.C.J.M. State-of-the-art treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings // J. Vasc. Surg. — 2006. — Vol. 44. — Р. 1029-1038.
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