Abstract
This article describes the eye drops Viziloton (Dexpanthenol, Taurine, Hydroxymethyl cellulose) for mono- and combined therapy of eye surface disorders. It contains the review of the scientific literature regarding the impact of drug ingredients on the cornea and tear film. Understanding these mechanisms can reduce the side effects of treatment due to natural components.
References
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2. Göbbels M., Gross D. Clinical study of the effectiveness of a dexpanthenol containing artificial tears solution (Siccaprotect) in treatment of dry eyes // Klin. Monbl. Augenheilkd. — 1996 Aug. — Sep. — V. 209 (2-3). — Р. 84-8.
3. Baumeister M., Bühren J., Ohrloff C., Kohnen T. Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing // Ophthalmologica. — 2009. — V. 223 (6). — Р. 414-8.
4. Milicic N., Dukic A. Corneal epithelialization after PRK using sodium hyaluronate / dexpanthenol preservative-free eye drops. ESCRS. — 2015.
5. Oja S.S., Saransaari P. Pharmacology of taurine // Proc. West Pharmacol. Soc. — 2007. — V. 50. — Р. 8-15.
6. Ripps H., Shen W. Review: taurine: a «very essential» amino acid // Mol. Vis. — 2012. — V. 18. — Р. 2673-86. Epub. — 2012 Nov. — V. 12. Review.
7. Froger N., Moutsimilli L., Cadetti L., Jammoul F., Wang Q.P., Fan Y., Gaucher D., Rosolen S.G., Neveux N., Cynober L., Sahel J.A., Picaud S. Taurine: the comeback of a neutraceutical in the prevention of retinal degenerations // Prog. Retin. Eye Res. — 2014 Jul. — V. 41. — Р. 44-63.
8. Froger N., Jammoul F., Gaucher D., Cadetti L., Lorach H., Degardin J., Pain D., Dubus E., Forster V., Ivkovic I., Simonutti M., Sahel J.A., Picaud S. Taurine is a crucial factor to preserve retinal ganglion cell survival // Adv. Exp. Med. Biol. — 2013. — V. 775. — Р. 69-83.
9. Froger N., Cadetti L., Lorach H., Martins J., Bemelmans A.P., Dubus E., Degardin J., Pain D., Forster V., Chicaud L., Ivkovic I., Simonutti M., Fouquet S., Jammoul F., Léveillard T., Benosman R., Sahel J.A., Picaud S. Taurine provides neuroprotection against retinal ganglion cell degeneration // PLoS One. — 2012. — V. 7 (10). — Р. e42017.
10. Jammoul F., Dégardin J., Pain D., Gondouin P., Simonutti M., Dubus E., Caplette R., Fouquet S., Craft C.M., Sahel J.A., Picaud S. Taurine deficiency damages photoreceptors and retinal ganglion cells in vigabatrin-treated neonatal rats // Mol. Cell Neurosci. — 2010 Apr. — V. 43 (4). — Р. 414-21.
11. Hsu Y.W., Yeh S.M., Chen Y.Y., Chen Y.C., Lin S.L., Tseng J.K. Protective effects of taurine against alloxan–induced diabetic cataracts and refraction changes in New Zealand White rabbits // Exp. Eye Res. — 2012 Oct. — V. 103. — Р. 71-7.
12. ChenZhou L., Murube J., Latorre A., Martin del Rio R. Differentail presence of amino acids in human tears of normal and dry eyes // Cornea. — 2000. — V. 19. — Р. S80.
13. Thimons J.J. Examining Taurine’s Role in Ocular Biochemistry and in Contact Lens Wear. Contact Lens Spectrum. — 2004 Apr.
14. Baudouin C., Aragona P., Messmer E.M., Tomlinson A., Calonge M., Boboridis K.G., Akova Y.A., Geerling G., Labetoulle M., Rolando M. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting // Ocul. Surf. — 2013 Oct. — V. 11 (4). — Р. 246-58.
15. Shioda R., Reinach P.S., Hisatsune T., Miyamoto Y. Osmosensitive taurine transporter expression and activity in human corneal epithelial cells // Invest. Ophthalmol. Vis. Sci. — 2002 Sep. — V. 43 (9). — Р. 2916-22.
2. Göbbels M., Gross D. Clinical study of the effectiveness of a dexpanthenol containing artificial tears solution (Siccaprotect) in treatment of dry eyes // Klin. Monbl. Augenheilkd. — 1996 Aug. — Sep. — V. 209 (2-3). — Р. 84-8.
3. Baumeister M., Bühren J., Ohrloff C., Kohnen T. Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing // Ophthalmologica. — 2009. — V. 223 (6). — Р. 414-8.
4. Milicic N., Dukic A. Corneal epithelialization after PRK using sodium hyaluronate / dexpanthenol preservative-free eye drops. ESCRS. — 2015.
5. Oja S.S., Saransaari P. Pharmacology of taurine // Proc. West Pharmacol. Soc. — 2007. — V. 50. — Р. 8-15.
6. Ripps H., Shen W. Review: taurine: a «very essential» amino acid // Mol. Vis. — 2012. — V. 18. — Р. 2673-86. Epub. — 2012 Nov. — V. 12. Review.
7. Froger N., Moutsimilli L., Cadetti L., Jammoul F., Wang Q.P., Fan Y., Gaucher D., Rosolen S.G., Neveux N., Cynober L., Sahel J.A., Picaud S. Taurine: the comeback of a neutraceutical in the prevention of retinal degenerations // Prog. Retin. Eye Res. — 2014 Jul. — V. 41. — Р. 44-63.
8. Froger N., Jammoul F., Gaucher D., Cadetti L., Lorach H., Degardin J., Pain D., Dubus E., Forster V., Ivkovic I., Simonutti M., Sahel J.A., Picaud S. Taurine is a crucial factor to preserve retinal ganglion cell survival // Adv. Exp. Med. Biol. — 2013. — V. 775. — Р. 69-83.
9. Froger N., Cadetti L., Lorach H., Martins J., Bemelmans A.P., Dubus E., Degardin J., Pain D., Forster V., Chicaud L., Ivkovic I., Simonutti M., Fouquet S., Jammoul F., Léveillard T., Benosman R., Sahel J.A., Picaud S. Taurine provides neuroprotection against retinal ganglion cell degeneration // PLoS One. — 2012. — V. 7 (10). — Р. e42017.
10. Jammoul F., Dégardin J., Pain D., Gondouin P., Simonutti M., Dubus E., Caplette R., Fouquet S., Craft C.M., Sahel J.A., Picaud S. Taurine deficiency damages photoreceptors and retinal ganglion cells in vigabatrin-treated neonatal rats // Mol. Cell Neurosci. — 2010 Apr. — V. 43 (4). — Р. 414-21.
11. Hsu Y.W., Yeh S.M., Chen Y.Y., Chen Y.C., Lin S.L., Tseng J.K. Protective effects of taurine against alloxan–induced diabetic cataracts and refraction changes in New Zealand White rabbits // Exp. Eye Res. — 2012 Oct. — V. 103. — Р. 71-7.
12. ChenZhou L., Murube J., Latorre A., Martin del Rio R. Differentail presence of amino acids in human tears of normal and dry eyes // Cornea. — 2000. — V. 19. — Р. S80.
13. Thimons J.J. Examining Taurine’s Role in Ocular Biochemistry and in Contact Lens Wear. Contact Lens Spectrum. — 2004 Apr.
14. Baudouin C., Aragona P., Messmer E.M., Tomlinson A., Calonge M., Boboridis K.G., Akova Y.A., Geerling G., Labetoulle M., Rolando M. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting // Ocul. Surf. — 2013 Oct. — V. 11 (4). — Р. 246-58.
15. Shioda R., Reinach P.S., Hisatsune T., Miyamoto Y. Osmosensitive taurine transporter expression and activity in human corneal epithelial cells // Invest. Ophthalmol. Vis. Sci. — 2002 Sep. — V. 43 (9). — Р. 2916-22.
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